Includes cards used by Yugi Muto/Yami Yugi, Joey Wheeler, Seto Kaiba, Zane Truesdale, Jesse Anderson, Yusei Fudo, Nash, Kite Tenjo, Z-ARC, Yuri, Yusaku Fujiki, Skye Zaizen, and Ai.

Introduces new members/support for the "Barian's", "Crystal Beast", "CXyz", "Fusion", "Fusion Dragon", "Infernity", "Number", "Number 10X", "Number C", "Pendulum Dragon", "Performapal", "Polymerization", "Rank-Up-Magic", "Red-Eyes", "Resonator", "Supreme King", "Supreme King Gate", "Synchron", "Synchro Dragon", "Utopia", "Utopic", and "Xyz Dragon" archetypes, as well as the Firewall, Overlay, and Signature move series.

Includes 24 new cards that call to mind famous scenes from throughout the Yu-Gi-Oh! franchise, 4 for each anime series.

Includes reprint of members/support for the "Blue-Eyes", "Code Talker", "Crystal", "Crystal Beast", "CXyz", "Dark Magician", "Dark Magician Girl", "Elemental HERO", "Fusion", "Fusion Dragon", "Galaxy", "Galaxy-Eyes", "HERO", "Junk", "Kuriboh", "Magician Girl", "Neos", "Number", "Number", "Number C", "Number 10X", "Pendulum Dragon", "Photon", "Rank-Up-Magic", "Red-Eyes", "Starving Venom", "Supreme King", "Supreme King Dragon", "Supreme King Gate", "Synchro Dragon", "Synchron", "Trickstar", "Ultimate Crystal", "Utopic", "Utopic Future", "Venom", and "Xyz Dragon" archetypes, as well as the Chimeratech, Cosmic Synchro Monster, -Eyes Dragon, Four Dimension Dragons, and Number F series.

Includes 3 monsters with variant artworks.